Catalysis with metals
Ferrocene ligands
Asymmetric catalysis is at the forefront of modern organic synthesis. Complexes of chiral ferrocene-based ligands with transition metals are one of the major groups of enantioselective catalysts, effective for a wide range of asymmetric reactions. Our research group, therefore, investigates synthesis and applications of new ferrocene ligands in asymmetric catalysis. Futhermore, we broaden synthetic utility of known ferrocene catalysts by developing new stereoselective reactions. At present we focus on combination of several stereoselective reactions into an one-pot transformation.
Asymmetric catalysis is at the forefront of modern organic synthesis. Complexes of chiral ferrocene-based ligands with transition metals are one of the major groups of enantioselective catalysts, effective for a wide range of asymmetric reactions. Our research group, therefore, investigates synthesis and applications of new ferrocene ligands in asymmetric catalysis. Futhermore, we broaden synthetic utility of known ferrocene catalysts by developing new stereoselective reactions. At present we focus on combination of several stereoselective reactions into an one-pot transformation.
We are interested in these reactions with Grignard reagents as nucleophiles for conjugate addition to produce chiral magnesium enolates. As electrophile we choose:
- imines [see Eur. J. Org. Chem. 2012, 6285-6290, Eur. J. Org. Chem. 2011, 7092-7096, Eur. J. Org. Chem. 2010, 5666-5671]
- amidomethylating reagent [see J. Org. Chem. 2012, 77, 760-765]
- alkenes [see Tetrahedron: Asymmetry, 2015, 26, 271-275]
- carbenium ions [see Adv. Synth. Catal. 2015, 357, 1493-1498]
Preparation of silylated ferrocenyl derivatives we enabled through Retro-Brook rearrangement on O-silylated ferrocenyl alcohol initiated by Br-Li exchange. [see Chem. Eur. J. 2015, 21, 13445-13453]